Molecular Targeted Therapy

Nonbilayer Phase of Lipoplex–Membrane Mixture Determines Endosomal Escape of Genetic Cargo and Transfection Efficiency

Genetics / Technology / Atomic Force Microscopy / Biological Sciences / DNA / Molecular / Lipids / Cercopithecus aethiops / Animals / Therapy / Osmotic pressure / Liposomes / Plasmids / Gene Delivery / X ray diffraction / Transfection / Lipid bilayers / Molecular Targeted Therapy / Endosomes / Nucleic Acid / Molecular / Lipids / Cercopithecus aethiops / Animals / Therapy / Osmotic pressure / Liposomes / Plasmids / Gene Delivery / X ray diffraction / Transfection / Lipid bilayers / Molecular Targeted Therapy / Endosomes / Nucleic Acid

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DNA/dendrimer complexes mediate gene transfer into murine cardiac transplants ex vivo

Pharmacology / Technology / Gene expression / Biological Sciences / DNA / Molecular / Serotonin / Mice / Animals / Gene transfer techniques / Heart Transplantation / Vascular Permeability / Molecular Targeted Therapy / Quantitative Evaluation / Plasmid DNA / Polyethylene Glycols / Gene Transfer / Gene Expression Regulation / Cardiac Transplantation / Coronary artery / Molecular / Serotonin / Mice / Animals / Gene transfer techniques / Heart Transplantation / Vascular Permeability / Molecular Targeted Therapy / Quantitative Evaluation / Plasmid DNA / Polyethylene Glycols / Gene Transfer / Gene Expression Regulation / Cardiac Transplantation / Coronary artery

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Isocitrate lyase: a potential target for anti-tubercular drugs

Tuberculosis / Humans / Mycobacterium tuberculosis / Mice / Animals / Drug Design / Molecular Targeted Therapy / Drug Design / Molecular Targeted Therapy

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Tratamientos reparadores de la proteína CFTR en la fibrosis quística

Cystic Fibrosis / Humans / Mutation / Quinolones / Clinical Sciences / Molecular Targeted Therapy / Aminophenols / Molecular Targeted Therapy / Aminophenols

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Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth

Apoptosis / Gene Silencing / Signal Transduction / Dexamethasone / Humans / Child / Mice / Animals / Monoclonal Antibodies / L-asparaginase / Antineoplastic Agents / Molecular Targeted Therapy / Child / Mice / Animals / Monoclonal Antibodies / L-asparaginase / Antineoplastic Agents / Molecular Targeted Therapy

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Combination Angiostatin and Endostatin Gene Transfer Induces Synergistic Antiangiogenic Activity in Vitro and Antitumor Efficacy in Leukemia and Solid Tumors in Mice

Technology / Flow Cytometry / Gene Therapy / Immunohistochemistry / Leukemia / Cell separation / Western blotting / Cell Division / Biological Sciences / Molecular / Humans / Collagen / Mice / Female / Melanoma / Animals / Gene transfer techniques / Plasminogen / Proteoglycans / Endothelial cell / Time Factors / Transfection / Antitumor Activity / Recombinant Protein / Cell Survival / Tumor Growth / Antineoplastic Agents / Molecular Targeted Therapy / Gene Transfer / Angiogenesis inhibitor / Cell Growth / Down-Regulation / Laminin / Cell separation / Western blotting / Cell Division / Biological Sciences / Molecular / Humans / Collagen / Mice / Female / Melanoma / Animals / Gene transfer techniques / Plasminogen / Proteoglycans / Endothelial cell / Time Factors / Transfection / Antitumor Activity / Recombinant Protein / Cell Survival / Tumor Growth / Antineoplastic Agents / Molecular Targeted Therapy / Gene Transfer / Angiogenesis inhibitor / Cell Growth / Down-Regulation / Laminin

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A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma

Computational Biology / Membrane Proteins / Signal Transduction / RNA interference / Humans / Medulloblastoma / Cell Death / microRNAs / Neoplasm Invasiveness / Prognosis / Transfection / Cell Proliferation / Antineoplastic Agents / Molecular Targeted Therapy / RNAi Therapeutics / Gene expression profiling / Medulloblastoma / Cell Death / microRNAs / Neoplasm Invasiveness / Prognosis / Transfection / Cell Proliferation / Antineoplastic Agents / Molecular Targeted Therapy / RNAi Therapeutics / Gene expression profiling

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Array comparative genomic hybridization identifies novel potential therapeutic targets in cholangiocarcinoma

Genetics / Cancer / Survival Analysis / Immunohistochemistry / Treatment Outcome / Electrocardiography / DNA / Humans / Genetic Testing / Glioblastoma / Female / Nucleic acid hybridization / Renal cell Carcinoma / Male / Cluster Analysis / Long QT syndrome / Gene Dosage / Genes / Clinical Sciences / Aged / Middle Aged / Doxorubicin / Microarray Analysis / Adult / Cholangiocarcinoma / Retrospective Studies / Prognosis / Sudden Cardiac Death / Diffuse Large B-Cell Lymphoma / Reproducibility of Results / Individualized Medicine / DNA Copy Number / Cyclophosphamide / Molecular Targeted Therapy / Predictive value of tests / Brain Neoplasms / Comparative Genomic Hybridization / Array Comparative Genomic Hybridization / Gene expression profiling / Hematopoietic Stem Cell Transplantation / Electrocardiography / DNA / Humans / Genetic Testing / Glioblastoma / Female / Nucleic acid hybridization / Renal cell Carcinoma / Male / Cluster Analysis / Long QT syndrome / Gene Dosage / Genes / Clinical Sciences / Aged / Middle Aged / Doxorubicin / Microarray Analysis / Adult / Cholangiocarcinoma / Retrospective Studies / Prognosis / Sudden Cardiac Death / Diffuse Large B-Cell Lymphoma / Reproducibility of Results / Individualized Medicine / DNA Copy Number / Cyclophosphamide / Molecular Targeted Therapy / Predictive value of tests / Brain Neoplasms / Comparative Genomic Hybridization / Array Comparative Genomic Hybridization / Gene expression profiling / Hematopoietic Stem Cell Transplantation

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842. Cell Permeable Peptides: Potential Use To Enhance Intracellular Gene Delivery

Technology / Gene Therapy / Biological Sciences / Gene Delivery / Transgene Expression / Molecular Targeted Therapy / Plasmid DNA / Gene Transfer / Molecular Targeted Therapy / Plasmid DNA / Gene Transfer

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Epigenetic Regulation of Lentiviral Transgene Vectors in a Large Animal Model

Pharmacology / Genetics / Technology / HIV / Biological Sciences / Molecular / Animals / DNA methylation / CpG islands / Transgenic Animals / Animal Model / Swine / Histone deacetylase inhibitor / Human Disease / Human Fibroblasts / Transgene Expression / Hydroxamic Acids / Molecular Targeted Therapy / Gene Transfer / Histone deacetylase inhibitors / Histone deacetylases / Molecular / Animals / DNA methylation / CpG islands / Transgenic Animals / Animal Model / Swine / Histone deacetylase inhibitor / Human Disease / Human Fibroblasts / Transgene Expression / Hydroxamic Acids / Molecular Targeted Therapy / Gene Transfer / Histone deacetylase inhibitors / Histone deacetylases

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A Target Repurposing Approach Identifies N-myristoyltransferase as a New Candidate Drug Target in Filarial Nematodes

Caenorhabditis elegans / Computational Biology / Biological Sciences / Animals / Drug Delivery Systems / Molecular Targeted Therapy

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In Utero Delivery of Adeno-Associated Viral Vectors: Intraperitoneal Gene Transfer Produces Long-Term Expression

Technology / Gene Therapy / Gene expression / Genetic Engineering / Biological Sciences / Molecular / Pregnancy / Mice / Female / Animals / Gene transfer techniques / Animal Model / Adeno-associated virus / Behavioral Animal Models / Gene Delivery / Fetus / Transgene Expression / Molecular Targeted Therapy / Whole Body / Peritoneal Cavity / Gene Transfer / Molecular / Pregnancy / Mice / Female / Animals / Gene transfer techniques / Animal Model / Adeno-associated virus / Behavioral Animal Models / Gene Delivery / Fetus / Transgene Expression / Molecular Targeted Therapy / Whole Body / Peritoneal Cavity / Gene Transfer

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Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats

Technology / Gene Therapy / Biological Sciences / Molecular / Liver / Animals / Gene transfer techniques / Polymerase Chain Reaction / Adeno-associated virus / Bilirubin / Rats / First Year / Crigler-Najjar syndrome / Rat Model / Molecular Targeted Therapy / Brain Damage / Serotyping / Bile / Animals / Gene transfer techniques / Polymerase Chain Reaction / Adeno-associated virus / Bilirubin / Rats / First Year / Crigler-Najjar syndrome / Rat Model / Molecular Targeted Therapy / Brain Damage / Serotyping / Bile

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Model of Unidirectional Transluminal Gene Transfer

Technology / Gene expression / Biological Sciences / Molecular / Humans / Animals / Green Fluorescent Protein / Glycosaminoglycans / Swine / Small samples / Molecular Targeted Therapy / Peritoneum / Gene Transfer / Experimental Model / Animals / Green Fluorescent Protein / Glycosaminoglycans / Swine / Small samples / Molecular Targeted Therapy / Peritoneum / Gene Transfer / Experimental Model

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Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells

Cancer / Cell Cycle / Nanomedicine / Cancer Biology / Nanotechnology / Transcription Factors / Pharmaceutical Chemistry / Apoptosis / Caspases / miRNA / Humans / Glioblastoma / Curcumin / Cell Death / microRNAs / Nanocapsules / Drug Carriers / Drug Stability / Molecular Targeted Therapy / Down-Regulation / Transcription Factors / Pharmaceutical Chemistry / Apoptosis / Caspases / miRNA / Humans / Glioblastoma / Curcumin / Cell Death / microRNAs / Nanocapsules / Drug Carriers / Drug Stability / Molecular Targeted Therapy / Down-Regulation

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SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

Technology / Confocal Microscopy / Western blotting / Biological Sciences / Heart Failure / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation / Cell line / Humans / Endothelial Cells / Congestive Heart Failure / Nitric oxide / Female / Animals / Gene transfer techniques / Endoplasmic Reticulum / Adeno-associated virus / Immunoprecipitation / Calcium Homeostasis / Endothelial Function / Endothelial cell / Swine / Protein Expression / Coronary Artery Disease / Vascular Reactivity / Molecular Targeted Therapy / Gene Transfer / Mitral regurgitation

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